New discoveries using the Bioruptor Pico. In this study, researchers discovered that Egr2 and 3 inhibit T-bet in CD4 and CD8 effector T cells using chromatin immunoprecipitation and reporter assays. Egr2 and 3 physically interact with the T-box domain of T-bet. This domain blocks T-bet DNA binding and inhibits T-bet–mediated IFN-γ production. Egr2 and 3[…]