Month: February 2018

TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs

Posted on by Emilie Chabot

Researchers in this new study found that TGFβ signaling is over-activated in DR-ESCs, and inhibition of TGFβ signaling eliminates the tumorigenicity of mESC-derived NPCs by inducing fully differentiation of DR-ESCs. The data showed that TGFβ-hyperactivated germ cell-like DR-ESCs are the main contributor for the tumorigenicity of ESCs-derived target cell therapy and that inhibition of TGFβ signaling[…]

Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics

Posted on by Emilie Chabot

For decades, major difficulties in analyzing histidine phosphorylation have limited the study of phosphohistidine signaling. Here researchers report a method revealing widespread and abundant protein histidine phosphorylation in Escherichia coli. They generated an extensive E. coli phosphoproteome data set, in which a remarkably high percentage  of phosphorylation sites are phosphohistidine sites. This resource should help enable a[…]

Article alert! MAX to MYCN ratio drives clinical outcome of neuroblastoma

Posted on by Emilie Chabot

Childhood neuroblastoma is the most common cancer that occurs in infancy. The MYCN oncogene has been shown to be a strong indicator for this cancer.  MYCN is a transcription factor that requires the expression of MAX to exert its function. In this new study, researchers illustrate that the MAX to MYCN ratio accounts for tumour progression and[…]