NeuroD1 is known to support and induce the neuronal differenciation during embryogenesis. Abhijeet Pataskar and colleagues discovered new epigenetics mechanisms underlying this essential role for the devlopment. Their ChIP-, FAIRE- and RNA-sequencing and motif analysis experiments show that NeuroD1 directly binds regulatory elements of neuronal genes that are embedded in heterochromatic environment. The induction of NeuroD1 initiates the reprogramming of[…]