Tag: bioruptor pico

Local adaptation and ecological differentiation under selection, migration and drift in Arabidopsis lyrata

Posted on by Emilie Chabot

New application using the Bioruptor for DNA shearing before library preparation: In this study, researchers conducted a reciprocal transplant trial, a common garden trial, and a whole‐genome based demography analysis to understand how selection, migration and drift influence local adaptation in Arabidopsis lyrata. In a three‐year field experiment, they showed evidence of local adaptation at the level of hierarchical[…]

New publication! Application of next-generation sequencing to characterize novel mutations in clarithromycin-susceptible Helicobacter pylori strains with A2143G of 23S rRNA gene

Posted on by Emilie Chabot

Clarithromycin (CLR) resistance has become a predominant factor for treatment failure of H. pylori eradication. Although the molecular mechanism of CLR resistance has been clearly understood in H. pylori, it is lack of evidence of other genes involved in drug resistance. Furthermore, the molecular mechanism of phenotype susceptible to CLR while genotype of 23S rRNA is mutant with[…]

TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs

Posted on by Emilie Chabot

Researchers in this new study found that TGFβ signaling is over-activated in DR-ESCs, and inhibition of TGFβ signaling eliminates the tumorigenicity of mESC-derived NPCs by inducing fully differentiation of DR-ESCs. The data showed that TGFβ-hyperactivated germ cell-like DR-ESCs are the main contributor for the tumorigenicity of ESCs-derived target cell therapy and that inhibition of TGFβ signaling[…]