NeuroD1 directly modifies chromatin to induce transcriptional reprogramming
NeuroD1 is known to support and induce the neuronal differenciation during embryogenesis. Abhijeet Pataskar and colleagues discovered new epigenetics mechanisms underlying this essential role for the devlopment. Their ChIP-, FAIRE- and RNA-sequencing and motif analysis experiments show that NeuroD1 directly binds regulatory elements of neuronal genes that are embedded in heterochromatic environment. The induction of NeuroD1 initiates the reprogramming of[…]