SPOC1 overexpression impacts HCMV replication

Posted on May 22, 2018May 22, 2018 by Emilie Chabot

Researchers here provide evidence that SPOC1 overexpression severely impairs HCMV replication by repressing the initiation of viral immediate early (IE) gene expression. SPOC1-depleted primary human fibroblasts displayed augmented initiation of viral IE gene expression. This occurs in a MOI-dependent manner, a defining hallmark of intrinsic immunity. Interestingly, repression requires the presence of high SPOC1 levels at[…]

SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin

Posted on May 9, 2018 by Emilie Chabot

In this study, researchers performed in-depth virological and cell biological studies and discovered that an inner nuclear membrane protein, SUN2, is a novel chromatin reassembly factor that maintains repressive chromatin and thus modulates HIV-1 transcription and latency. Targeting SUN2 may lead to new strategies for an HIV cure. The well-cited Bioruptor was used to[…]