In this new study, researchers identified a new CRL type E3 ligase ( which they termed CRL7SMU1) that has an essential role in chromatid cohesion maintenance. SMU1, DDB1, CUL7 and RNF40 were identified as main components of this new complex.  SMU1 by acting as a substrate recognition module, binds to H2B and mediates monoubiquitination at[…]