Researchers in this new study found that TGFβ signaling is over-activated in DR-ESCs, and inhibition of TGFβ signaling eliminates the tumorigenicity of mESC-derived NPCs by inducing fully differentiation of DR-ESCs. The data showed that TGFβ-hyperactivated germ cell-like DR-ESCs are the main contributor for the tumorigenicity of ESCs-derived target cell therapy and that inhibition of TGFβ signaling in ESC-derived NPC transplantation could drastically reduce the risk of tumor development. The Bioruptor Pico was essential to shear chromatin prior to ChIP-seq in this study. Read more!